Cytoreduction/HIPEC surgery for peritoneal mesothelioma involves two distinct parts: surgery and heated chemotherapy. Both are essential to completely debulking the abdominal cavity of tumors.

Both are integral to extending survival by precious weeks, months or even years for patients.

A new report in the American Journal of Translational Research explains how HIPEC, the heated chemotherapy part, improves the surgery as a whole. HIPEC stands for heated intraperitoneal chemotherapy.

The analysis included 44 patients with malignant peritoneal mesothelioma. The report focused on overall survival and inpatient recovery time, among other aspects.

All of the cases underwent cytoreductive surgery. This procedure often removes the omentum, peritoneal lining, and possibly other organs like the spleen. The idea of cytoreductive surgery is to take out the bulky tumors and any visible microscopic tumors.

In some cases, the tumors are too close to organs to be removed entirely. This is why patients need heated chemotherapy during the operation or another type of chemotherapy weeks later.

The patients either received HIPEC or dwell intraperitoneal chemotherapy weeks later as a second-line treatment. The three-year survival rate was nearly doubled in difference:

  • 65.22% three-year survival for the HIPEC group
  • 33.33% three-year survival for the systemic chemotherapy group

The reason HIPEC works so well is due to the direct access to the abdominal cavity. Surgeons and oncologists deliver the heated chemotherapy into the abdomen through catheters and wash the area in the tumor-killing toxins.

Substituting it for follow-up treatment either allows recurrence or doesn’t provide the same access to the disease area.

    Sources & Author

Devin Goldan image

About the Writer, Devin Golden

Devin Golden is the content writer for Mesothelioma Guide. He produces mesothelioma-related content on various mediums, including the Mesothelioma Guide website and social media channels. Devin's objective is to translate complex information regarding mesothelioma into informative, easily absorbable content to help patients and their loved ones.

Guide Packet Desktop Ad

Want to learn more?

Try Our Free Guide to Fighting Mesothelioma

Get in depth knowledge about your diagnosis & the best treatments.

Learn More
Guide Packet Mobile Ad