Diagnosing mesothelioma is a challenge. Avoiding a mesothelioma misdiagnosis is vital to getting effective treatment.
Written by Jenna Campagna, RN
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Important Facts About Mesothelioma Misdiagnosis
- Misdiagnosis of mesothelioma occurs frequently because the cancer is rare. Doctors mistake it for other illnesses, like pneumonia or lung cancer.
- Doctors also misdiagnose mesothelioma by stage, which impacts treatment.
- Second opinions help defend against a misdiagnosis. Receiving additional input from a specialist will either confirm the diagnosis or provide new information.
What Does a Mesothelioma Misdiagnosis Mean for You?
A mesothelioma misdiagnosis is an incorrect mesothelioma-related diagnosis. This can be:
- A doctor diagnosing another cancer or condition to someone who has mesothelioma
- Someone receiving a mesothelioma diagnosis when they actually have a different disease
- A patient being misdiagnosed by stage
Mesothelioma is one of the rarest diseases known to medicine. According to the American Cancer Society, no more than 3,000 new cases occur in the United States each year.
Because of its scarcity, most general physicians and private-practice doctors don’t recognize mesothelioma. Additionally, detection methods are not 100% accurate.
Misdiagnosing mesothelioma also occurs because this cancer shares similarities to other health conditions. For example, many mesothelioma symptoms are the same as those of influenza.
To avoid a misdiagnosis, you should:
- Receive your diagnosis from a mesothelioma specialist
- Undergo numerous tests, including a tissue biopsy
- Get a second opinion to double-check the diagnosis
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Common Illnesses in a Misdiagnosis
Some common illnesses in a mesothelioma misdiagnosis are pneumonia and irritable bowel syndrome. These misdiagnoses occur due to common symptoms.
Early detection of mesothelioma is still a long way from perfection, but there is ongoing research to make it more accurate. Currently, the best way to diagnose mesothelioma is through a mesothelioma biopsy. Doctors use tissue biopsies after imaging tests reveal visual evidence of the cancer.
However, some doctors may not recognize mesothelioma on imaging scans. Instead, they will attribute the symptoms to less-severe, noncancerous conditions.
Most patients make their first visit to the doctor due to complaining of common symptoms:
- Difficulty breathing
- Chest or abdominal pains
Chest or abdominal pains are caused by fluid buildup (known as effusions) in the chest or abdomen. These effusions show up on imaging tests but can be mistaken for another condition.
Chest pains and shortness of breath are symptoms of pleural mesothelioma. However, they are common symptoms of other respiratory ailments such as pneumonia.
Abdominal pains and indigestion are symptoms of peritoneal mesothelioma. This mesothelioma can be confused with irritable bowel syndrome.
Cancers Confused With Mesothelioma
In addition to being mistaken for common illnesses, mesothelioma is confused with other cancers.
Pleural mesothelioma has been confused with several types of lung cancer — most notably, adenocarcinoma, a non-small-cell lung cancer. Pleural mesothelioma forms in the pleura, which is the protective membrane between your chest wall and lung cavity. The neighborly relationship between your pleura and lungs explains why pleural mesothelioma is confused with lung cancer.
Peritoneal mesothelioma is confused with ovarian cancer. The peritoneum, which is where peritoneal mesothelioma forms, is a thin lining that wraps around your abdominal cavity. This lining is close to the ovaries, and around half of peritoneal mesothelioma cases involve women.
Trouble With Scans
Doctors often suspect common cancers to be the cause of a tumor when they order X-rays and computed tomography scans. These scans are only useful up to the point of locating tumors. Biopsies are required to get an accurate diagnosis.
Difficulties in Pathology
Mesothelioma pathology involves examining biopsy samples. Specialists study the cellular structure of the tissue or fluid sample to determine if it is mesothelioma. Pathologists can make mistakes when it comes to diagnosing these samples because some cancers have similar cellular structures to mesothelioma. Additionally, it’s possible the pathologist has never encountered mesothelioma before.
Fluid Samples Are Unreliable
The biggest struggle in diagnosing mesothelioma involves fluid biopsies. Fluid buildup is a common symptom of mesothelioma, and collecting fluid samples from around the lungs or abdomen is a noninvasive diagnostic method. It’s easier to extract fluid than tissue.
However, it is harder to examine cells under the microscope with fluid samples. Cells are suspended in fluid, which is tougher to test, and the samples don’t provide many cells. Tissue samples have far more cells.
Fortunately, medical evolution has helped in preventing mesothelioma misdiagnosis. Fine-needle aspirations and camera-assisted tissue biopsies have emerged as an alternative to large incisions. The camera-assisted needle biopsies for mesothelioma are thoracoscopy (for pleural mesothelioma) and laparoscopy (for peritoneal mesothelioma).
Misdiagnosis of Mesothelioma by Stage
Mesothelioma can be misdiagnosed by stage. This affects treatment.There are four mesothelioma stages. Some patients initially diagnosed with a later stage of mesothelioma may learn their disease isn’t as advanced. Other patients may learn their disease is more advanced than initially thought.
Misdiagnosis by stage occurs simply because every patient is different. While there are general symptoms for each stage, some patients may experience symptoms at different times.
Doctors also may use different systems for staging. There isn’t an exact science to staging this cancer. The practice of staging mesothelioma involves the doctor making an estimation based on the size of tumors and where they’ve spread. Other doctors may stage based on symptoms.
A study published in the Journal of Thoracic Oncology inspected 1,056 mesothelioma patients. The researchers analyzed how often a misdiagnosis occurred for each stage:
- 80.8% of stage 1 mesothelioma diagnoses were incorrect and later “upstaged” to a more-advanced stage.
- 69.5% of stage 2 mesothelioma cases were misdiagnosed.
- 35.4% of stage 3 mesothelioma diagnoses were inaccurate.
- 12.8% of stage 4 mesothelioma cases were misdiagnosed, and later “downstaged.”
Most changes involved upstaging the cancer to a more-advanced stage:
- Approximately 47% of patients were upstaged.
- Only 4.6% were downstaged.
If you’re diagnosed with malignant mesothelioma, it is imperative to receive a second opinion from a specialist. A definitive diagnosis is the key to getting effective treatment.
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How Does a Mesothelioma Misdiagnosis Affect Treatment Options?
Mesothelioma treatment is different from other types of cancer. If you receive an incorrect diagnosis, then you may be delayed receiving treatment or undergoing surgery.
A misdiagnosis by stage is particularly important in the treatment options available for patients. Curative surgeries, for example, are determined based on the patient’s stage. Earlier-stage patients are more likely to be candidates for surgery.
If you’re diagnosed with a more severe mesothelioma than you actually have, you might be denied curative therapies. If you experience a misdiagnosis that was more optimistic than the true diagnosis, then you may undergo an unnecessary surgery.
Even if you received a misdiagnosis and your disease has progressed, there is hope for extending life. Research shows that palliative (pain-relief) treatments can have a benefit on life expectancy.
There are also clinical trials offering innovative treatment approaches not available to the general public. Clinical trials hold the potential to new hope.
The Next Step for Mesothelioma Misdiagnosis Prevention
Although a mesothelioma diagnosis is disheartening, it can be a blessing in disguise. Sometimes a misdiagnosis is more damaging to your prognosis than the actual diagnosis, which was the case for some mesothelioma survivors.
Even that new diagnosis was slightly off. She received another opinion, this one from a specialist, who diagnosed her with stage 2 pleural mesothelioma. She was a candidate for aggressive treatment, which has helped her survive for around two decades.
Jodi knows the value of second opinions, stating it made “a huge difference” in terms of available treatment options. She was originally misdiagnosed with advanced pleural mesothelioma, but a second opinion proved she was eligible for life-saving surgery.
Getting a proper diagnosis from a specialist is the primary way patients can limit the damage of a mesothelioma misdiagnosis. Find a specialist for your diagnosis with our free Doctor Match program.
Common Questions About Mesothelioma Misdiagnosis
Can mesothelioma be misdiagnosed?
Doctors frequently misdiagnose mesothelioma, especially if they’re not specialists. Only around 3,000 new cases emerge each year in the United States, and many doctors have never treated a patient before. The commonality of most mesothelioma symptoms to other illnesses often leads to mistakes.
What is mesothelioma often misdiagnosed as?
Mesothelioma is confused with a lot of diseases and illnesses, even other cancers. Some of the most common misdiagnoses are:
- Irritable bowel syndrome
- Lung cancer
- Ovarian cancer
Can mesothelioma be misdiagnosed as COPD?
Chronic obstructive pulmonary disease (COPD) limits airflow from the lungs due to inflammation of the organ’s tissue. Mesothelioma forms in the lining of the lungs and usually spreads to this organ, so advanced forms of mesothelioma can be misdiagnosed as COPD. The shared symptoms are coughing and difficulty breathing.
Sources & Author
- Key Statistics About Malignant Mesothelioma. American Cancer Society. Retrieved from:
https://www.cancer.org/cancer/malignant-mesothelioma/about/key-statistics.html. Accessed: 06/12/2020.
- Initial Analysis of the International Association For the Study of Lung Cancer Mesothelioma Database. Journal of Thoracic Oncology. Retrieved from: https://www.jto.org/article/S1556-0864(15)33132-4/fulltext. Accessed: 06/12/2020.