Stage 2 mesothelioma involves the lining of one lung and part of the diaphragm. Curative surgery is used depending on the patient's overall health.

The Beginning of Metastasis

Stage 2 MesotheliomaStage 2 mesothelioma is still localized to the area in which it originated from. Although it hasn’t spread to other organs, there has been minor metastasis to the lymph nodes.

Patients at this stage are still candidates for aggressive treatment options that can improve their life expectancy.

Stage 2 Treatment Options

  • Extrapleural Pneumonectomy

    An extrapleural pneumonectomy is the complete removal of the affected lung, pleura and part of the diaphragm. It is commonly used on stage 2 pleural mesothelioma patients.

  • Pleurectomy with Decortication

    A pleurectomy is the removal of the pleura. The pleura is the first place that mesothelioma tumors begin to grow in pleural mesothelioma patients.

  • Cytoreduction

    A cytoreduction is the removal of the peritoneum, which is the lining of the abdomen. Patients with stage 2 peritoneal mesothelioma are common candidates for cytoreduction surgery.

At this point, curative surgery can be used depending on the strength of the patient. Although stage 2 mesothelioma is the beginning of metastasis, there is still a lot of hope for treatment.

What to Expect

  • As far as symptoms, patients may experience pain when breathing, coughing, shortness of breath, unexplained weight loss or lumps in the chest or abdomen.
  • Surgery is usually used in patients with stage 2 mesothelioma, for both curative and palliative purposes. Patients can expect chemotherapy, radiation, and other medical treatments following surgery.
  • Patients with stage 2 mesothelioma are usually candidates for curative surgical options. Those with pleural mesothelioma can undergo an extrapleural pneumonectomy or a pleurectomy. Patients with peritoneal mesothelioma can get cytoreduction surgery with HIPEC.
  • Patients should be prepared to get a second opinion concerning their diagnosis. In getting a second opinion, patients can be sure that the diagnosis they receive is the right one and they can get the necessary treatment.

Treatment Options

Patients with stage 2 mesothelioma are considered early stage patients. Stage 2 patients can be treated with curative options as well as palliative options. Chemotherapy and radiation are used before and after surgery to help remove any remaining cancer cells or tumors.

Some basic characteristics of stage 2 mesothelioma are:

  • Tumors have grown beyond point of origin and there is some lymph node involvement
  • Symptoms may become more obvious as the cancer metastasizes
  • Surgery is available for both curative and palliative purposes
In stages 1 and 2, curative surgeries are more common because the mesothelioma is centralized. Surgery has a higher probability to remove most or all of the mesothelioma.


The prognosis for patients with stage 2 mesothelioma is generally positive. Due to the treatment options, life expectancy is increased and the ability to treat the cancer sooner is possible. The cancer is still considered treatable because of the limited cancer spread.

Patients with stage 2 mesothelioma live an average of 16 months, but many patients have exceeded that expectancy rate.

In stages 1 and 2, curative surgeries are more common because the mesothelioma is centralized. Surgery has a higher probability to remove most or all of the mesothelioma.

One study conducted in the 1990s showed that stage 2 patients have a 60 percent chance of living 12 months or longer after receiving a pleurectomy with decortication.

Another study that was done by leading thoracic surgeon, David Sugarbaker, suggests that 50 percent of stage 2 patients can live up to 20 months. This evidence comes from patients who have received an extrapleural pneumonectomy.

There is an ongoing debate as to which of these surgical procedures are more effective. However, the best procedure is more likely to depend on the individual diagnosis.

Get connected with a specialist who can offer the most effective procedure for you.

Stage 2 by Different Staging Systems

  • Stage 2 (Butchart System)

    The Butchart System stages the mesothelioma depending on the size of the tumor. According to the Butchart system, the mesothelioma may have spread to the esophagus, or the pericardial membrane.

  • Stage 2 (Brigham System)

    The Brigham System is the newest staging system out of the three. The Brigham System devotes more attention to the surgery surrounding the mesothelioma. Depending on the candidate, the cancer can be removed by surgery.

  • Stage 2 (TNM System)

    According to the TNM (Tumor, Nodes, and Metastasis) System, cancer has spread to the lining of the lungs, diaphragm, close lymph nodes and possibly the lining of the heart on one side of the body.