Treating Pleural and Peritoneal Mesothelioma with LMB-100 and SEL-110

Screening Pleural and Peritoneal Mesothelioma Candidates

The study is currently recruiting pleural and peritoneal mesothelioma patients. To be a successful candidate for the trial, an individual must have participated in at least one cycle of chemotherapy.

Candidates will undergo a series of screenings for the trial. Participants will be asked about their medical history and they will be given a physical exam. Patients must also be willing to provide a sample of their tumor tissue.

Additional tests will be given to ensure the safety of all of the trial’s participants.

Enrollees will also experience:

• Blood and urine tests
• Heart function tests
• Scans of their chest, abdomen, and pelvis
• Positron emission tomography (FDG-PET) scan

A patient must be willing to repeat some of the tests while they are receiving treatment in the trial. They must also be available to complete some of the exams after they’ve completed their final treatment session.

What to Expect: Getting Treated With LMB-100 and SEL-110

The trial will be conducted in 21-day cycles. Participants will receive both LMB-100 and SEL-110 by an IV infusion. Each patient will be given the drug combination for up to 4 treatment cycles.

A participant will be given LMB-100 for approximately 30 minutes on days 1, 3, and 5 of each cycle. For about an hour on day 1 of every treatment cycle, a patient will receive the drug SEL-110.

Is This Clinical Trial for You?

Lead investigator of the study is mesothelioma specialist, Dr. Raffit Hassan. Dr. Hassan plays an active role in improving treatment for mesothelioma patients. His research includes using mesothelin as a target for cancer therapy and immunotherapy.

This study is sponsored by the National Cancer Institute and is looking for participants to enroll at their National Institutes of Health Clinical Center in Bethesda, Maryland. The clinical trial plans to accept about 40 participants.

To guarantee the safety of participants, there are some criteria that a patient must meet.

Patient Inclusions:

• Confirmed diagnosis of peritoneal or pleural mesothelioma
• Mesothelioma cell type is either epithelial or biphasic
• At least 1 round of first-line chemotherapy
• Not considered a surgical candidate

For more information about this trial or any other recruiting clinical trial, please contact Jenna Campagna. You can reach her at 888-385-2024 extension 102 or by emailing jenna@mesotheliomaguide.com.